Patients were twice as likely to have a diabetic foot ulcer heal within eight weeks when they were treated with a tissue repair drug versus a placebo, according to new research published in the Journal of Clinical Endocrinology & Metabolism ( JCEM ).
Foot ulcers are a common complication from diabetes than can lead to hospitalization and lower limb amputation. In 2006, about 65,700 non-traumatic lower-limb amputations were performed in people with diabetes, according to the Centers for Disease Control and Prevention ( CDC ).
Up to 85% of amputations can be avoided when ulcers are prevented from forming or are treated successfully.
Foot ulcers are a dangerous and expensive complication for people with diabetes, and current treatments such as hyperbaric oxygen therapy are costly and can have side effects.
The study showed for the first time that a pharmacological approach can improve wound healing in people with diabetes.
In the prospective randomized, double-blinded, placebo-controlled clinical trial, 216 participants with diabetic foot ulcers free of visible infection were assigned to receive either the tissue repair drug Polydeoxyribonucleotide ( PDRN ) or a placebo.
Participants received injections of either Polydeoxyribonucleotide or a placebo for eight weeks and were monitored for an additional four weeks for any change in the ulcer.
After two months, 37% of the patients who were treated with Polydeoxyribonucleotide had their ulcers completely closed, compared with nearly 19% of the patients who received the placebo.
Study subjects reported few side effects from Polydeoxyribonucleotide.
This approach could revolutionize the treatment of diabetic foot ulcers, a main cause of hospital admissions in the developed world.
An estimated 382 million people worldwide have diabetes, and it is crucial to find effective treatment options for hard-to-heal ulcers and other complications facing millions of patients. ( Xagena )
Source: The Endocrine Society, 2014