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People with impaired glucose tolerance: association between cardiovascular events and change in daily ambulatory activity


The extent to which change in physical activity can modify the risk of cardiovascular disease in individuals at high cardiovascular risk is uncertain.
Researchers have investigated whether baseline and change in objectively-assessed ambulatory activity is associated with the risk of a cardiovascular event in individuals at high cardiovascular risk with impaired glucose tolerance.

Researchers have assessed prospective data from the NAVIGATOR trial involving 9306 individuals with impaired glucose tolerance who were recruited in 40 countries during the period 2002-2004.
Participants also either had existing cardiovascular disease ( if age greater than or equal to 50 years ) or at least one additional cardiovascular risk factor ( if age greater than or equal to 55 years ).

Participants were followed-up for cardiovascular events ( defined as cardiovascular mortality, non-fatal stroke, or myocardial infarction ) for 6 years on average and had ambulatory activity assessed by pedometer at baseline and 12 months.

During 45 211 person-years follow-up, 531 cardiovascular events occurred. Baseline ambulatory activity ( hazard ratio [ HR ] per 2000 steps per day 0.90 ) and change in ambulatory activity ( 0.92 ) were inversely associated with the risk of a cardiovascular event.

Results for change in ambulatory activity were unaffected when also adjusted for changes in body-mass index and other potential confounding variables at 12 months.

In individuals at high cardiovascular risk with impaired glucose tolerance, both baseline levels of daily ambulatory activity and change in ambulatory activity display a graded inverse association with the subsequent risk of a cardiovascular event. ( Xagena )

Yates T et al, The Lancet 2014; 383: 1059-1066

XagenaMedicine_2014



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